Wednesday, 20 August 2014

John Cruwys and Sarah Chown of Tiverton, Devon

Richard Chilcott has very kindly sent me this wonderful photograph of John Cruwys (1860-1919), Sarah Chown/Quant (1851-1921) and their daughter Winifred May Cruwys (1897-1983). The photograph is from the collection of Leslie Cruwys and is published with his permission.
John's wife Sarah Chown had previously been married to John Henry Quant (1850-1881) by whom she had three children. She married John Cruwys in 1882 a year after the death of her first husband. John and Sarah had eight children together, and Winifred was the youngest of their children.

John Cruwys is from the Witheridge Cruwys tree which can be traced back to William Cruwys and Sarah Taylor who married on 2nd February 1820 in Witheridge, Devon. William is probably the William Purchase Cruys, who was baptised on 2nd November 1794 in Cheriton Fitzpaine and was the illegitimate son of Sarah Cruys.

John Cruwys worked as a stonemason. His family remember that he lost a leg following an accident. Indeed the accident might possibly have occurred in 1901 because in the 1901 census George was a patient at St George's Hospital in Hanover Square in London. I was told a story by a local resident that John had skills as a carpenter and that if he ever broke his artificial leg he would go home and make himself another one! It was thought that he made his legs from chair legs strapped on from the knee down. You can clearly see from the crease in John's trousers that he has an artificial left leg just below the knee.

We don't know the exact date when the photograph was taken but Winifred looks as though she's in her early teens which would date the photo to about 1910. In the 1911 census John and Sarah were living at Jurishayes Cottage in Tiverton and the photograph is almost certainly taken outside their house.

Tuesday, 29 July 2014

Family Tree DNA reduce the price of the Big Y test to $595

I wrote at the weekend about the new Y Prime test from Full Genomes which is designed as a competitor to Family Tree DNA's Big Y test. Family Tree DNA have now responded by announcing a permanent reduction in the price of their Big Y test, and they have also introduced a few new features to the Big Y display. Note that FTDNA's Big Y is only available to existing FTDNA customers. It's good to see some healthy competition in the Y-DNA testing market. Here is the text of the e-mail that was sent out to project administrators:

Dear Project Administrators,

We are excited to announce the release of a new feature to help Big Y testers refine their matches!  Now, you'll be able to easily filter out matches that aren't genealogically relevant to you.

Also, as part of this release we are permanently reducing the price of Big Y to $595.  
How it Works
The filter lists the subclades immediately upstream from the tester's terminal subclade.  When a subclade has been selected, a number appears next to the unselected subclades to indicate how far upstream or downstream they are from the selected subclade.

A subclade marked (+1) is the next clade upstream from the currently selected clade.  A subclade marked (-1) is the next clade downstream from the currently selected clade.  The number of matches available at each level is listed on the right side of the filter drop down. 


To help clarify the hierarchy of the subclades, the haplotree button has been updated to display subclades in the standard haplotree format.  The full tree can be viewed by clicking Go To Haplotree.  

Saturday, 26 July 2014

Full Genomes launches Y Prime - a new Y chromosome sequencing product

The following press release has been written by Full Genomes Corporation.

Full Genomes Corporation (FGC) is announcing today the introduction of a new Y chromosome sequencing product, dubbed Y Prime. The Y Prime test leverages recent technology advances to economically sequence large portions of a male's Y chromosome, enabling advanced, high-resolution tracing of direct paternal line ancestry.

FGC has worked with industry leaders to develop a new Y chromosome capture approach and has combined it with Illumina "next-gen" sequencing. The resulting data will be processed with the latest alignment algorithms to improve read mapping. The overall result is a cutting-edge product with Y chromosome coverage breadth that is close to that of FGC's original comprehensive Y sequencing product (now termed Y Elite), at a much lower cost. Additionally, the new product is priced lower than the leading competitor, while retaining a significant advantage in terms of quality and comprehensiveness.

FGC is releasing the following comparison statistics as estimates of test coverage based on Y Prime pilot results.



Y Prime will be offered at a standard price of $625. An introductory price of $599 is available for orders placed by August 31, 2014. Y Prime is currently available at the discounted introductory price through the Full Genomes website by ordering the Comprehensive Y test using the coupon code "YPRIME".

The new product is also expected to offer significant improvements in turnaround time for results. Testing will be performed by a U.S.-based sequencing facility.

Additionally, FGC has recently been developing new sample collection protocols, designed to reduce the frequency of delays due to the need for repeat sample collection.

Justin Loe, CEO of FGC, commented, "Our new product is consistent with our mission to deliver the best quality Y sequencing products at the most affordable prices possible, and to continue to innovate with new products targeted to the genetic genealogy community."

FGC will continue to offer the original comprehensive Y sequencing product, with sequencing performed at BGI, under the new name Y Elite. To help customers decide which product is right for them, FGC is releasing BED files to indicate the regions covered by representative tests; these are available at http://goo.gl/pcq6FE and can be used to determine whether a particular site or SNP of interest is likely to be covered by the test. Customers with questions may contact orders@fullgenomes.com.

DAK note: I am advised that Greg Magoon has further technical comparisons available, which are the raw data files from the pilot samples (BAM files and FGC analytical reports), that are also available for comparison for specialists.

Update 29 July 2014
Full Genomes have announced that the Y Prime test will be offered at a new low price of $589.

Friday, 25 July 2014

My letter in Family Tree Magazine about "genetic homeland" stories

The August 2014 issue of Family Tree Magazine includes a letter I wrote in response to two stories in their July issue which claimed that it is possible to identify someone's "genetic homeland" from a DNA test. There was not space in the magazine to include the full text of my letter and the editor has kindly given me permission to reproduce the full letter here.
In your July issue you published two articles which claimed to show that it is possible to pinpoint your "genetic homeland" a thousand or more years ago by taking a simple DNA test. It would indeed be wonderful if a DNA test could give us this information but sadly it is not possible. 
The first story “DNA: find your ancestral home” (p9) referred to a new autosomal DNA test developed by a company called Prosapia Genetics. They claim that they are able to pinpoint someone’s genetic homeland one thousand years ago and that their test is “accurate to home village with a time resolution of the past 1,000 years”. The underlying research on which this test is based was published in a scientific journal (Elhaik et el 2014, Nature Communications 5: 3513). However, the researchers were only able to place 50% of people within 450 kilometres of their country of origin, which is hardly the level of precision claimed. Furthermore the research focused solely on the present-day country of origin and made no attempt to determine an ancestral origin one thousand years ago. Such a method is best thought of as human provenancing – finding the location where an individual’s genotype is most likely to be found – not a method for inferring ancestry. Indeed, if you go back one thousand years you have in theory about 35 billion ancestors, although you actually inherited DNA from only a small, random subset of those ancestors. Identifying a single location as the “genetic homeland” of either all your pedigree ancestors or just the DNA ancestors would be a meaningless exercise. The International Society of Genetic Genealogy received a number of reports from dissatisfied customers of Prosapia Genetics, many of whom had received bizarre results placing their "genetic homeland" in the middle of a river or ocean. Fortunately they were able to get refunds from PayPal. 
Dr Tyrone Bowes, the author of the second article "Routes to roots" (pp14-18), claims to be able to tell his customers when their ancestors arrived in Britain and where they came from based on recurring surname matches received as part of a commercial Y-chromosome DNA test. DNA testing is a very useful tool for the genealogist, and Y-DNA matches can often provide clues about our recent origins. However, Y-DNA results should always be interpreted in combination with genealogical and historical records. While a Y-DNA test is very good at indicating whether or not two people share a recent male-line ancestor, it is much more difficult to determine precisely when or where that ancestor might have lived. For example, a match on 34 out of 37 markers could indicate a shared ancestor who lived 200 years ago or 2000 years ago, and there is no way of determining the precise timeframe. Furthermore, surnames did not become common in Britain one thousand years ago, as is claimed. They were introduced into Britain with the Norman Conquest but the adoption of surnames was a gradual process. While most English people had acquired surnames by the fifteenth century, surnames were not adopted until the nineteenth century in some parts of Wales. In the Highlands of Scotland the clan system survived until the eighteenth century, and people adopted the name of the clan rather than using an hereditary surname. Even when surnames are passed on through the fatherline the link between the Y-chromosome and the surname is often broken as a result of illegitimacy, cuckoldry, adoption or name changes. In addition, there is an inherent American bias in the commercial databases. Consequently Y-DNA matches will often tell us more about non-paternity events in Colonial America in the last 400 years, rather than a person’s origins in the British Isles. All these factors need to be taken into account when interpreting DNA results. 
The mutations that determine haplogroups (the deep-rooted branches of the human Y-DNA tree) did indeed occur at a specific time and place several thousand years ago, but determining when and where that happened is a different matter entirely. We are reliant on making inferences from the DNA of living people. However, the current distribution of haplogroups differs from each of the distributions at different times in the past. The changes occur due to migration and the randomness of genetic drift. As more ancient DNA samples become available it might one day be possible to provide some answers, but we are not there yet and it is unlikely that we will ever be able to "precisely reconstruct our ancestral journey". 
Readers wishing to understand more about the legitimate uses of DNA testing for genealogy and the limited inferences that can be made from deep ancestry tests might like to refer to the new “Debunking genetic astrology” website that I have worked on with my colleagues at University College London: www.ucl.ac.uk/mace-lab/debunking. In particular readers might like to look at the page on dubious commercial claims (www.ucl.ac.uk/mace-lab/debunking/companies) where the genetic homeland stories are discussed in greater detail.
The editor also included in the August issue of Family Tree Magazine responses to my letter from Vladimir Makarov of Prosapia Genetics and Tyrone Bowes, the creator of the Irish, Scottish and English Origenes websites. Unfortunately, neither letter addressed any of the issues I'd raised. Vladimir Makarov argued that his reports do reflect ancient origins simply because the reference populations he uses are "totally agnostic of political boundaries". He failed to recognise that these reference populations are themselves possibly admixed and do not necessarily represent the population in the same location one thousand years ago. Tyrone Bowes went into great detail about a case report that he'd compiled for a Mr Valentine which purported to show a link with the McGregors. It seems that his entire dating method has been based on this single case. Numerous scientific studies have of course demonstrated that mutations occur at random, and any attempt to investigate the validity of matches must take into account the uncertainties in the TMRCA (time to the most recent common ancestor) calculations. My points about differing times of surname adoption and non-paternity events remained unanswered.

For further information about Prosapia Genetics and the case reports offered by the Irish, Scottish and English Origenes websites see my two earlier blog posts:

- Driving in the wrong direction with a dodgy DNA satnav (a critique of the test from Prosapia Genetics)
- A look at the genetic homeland case reports from English Origenes, Irish Origenes and Scottish Origenes


© 2014 Debbie Kennett